David Small


David’s research aims to understand mechanisms of cardiovascular and renal diseases using advanced microscopy tools that encompass the simultaneous and interacting functions at a microscopic scale in the true in vivo environment. The ultimate purpose of this research is to uncover rational therapeutic targets and strategies to improve organ function by targeting the interaction of different cell types. His work primarily focuses on heart failure and cardio-renal syndromes and uses innovative advances in multiphoton microscopy techniques in combination with preclinical mouse models, transgenic optobiology, and cell and molecular profiling

David obtained his PhD from the University of Queensland, Australia, under Prof Glenda Gobe. His PhD research investigated the pathological influence of oxidative stress in the development and progression of chronic kidney disease following acute injury, leading to publications in the field of experimental nephrology and presentations at national and international conferences. In 2015 David attended the Renal Division of the Brigham and Women’sHospital, Harvard Medical School under Prof Joe Bonventre as an ANZSN postdoctoral fellow to further his PhDfindings into cell cycle arrest in the kidney. Now at Cornell, David received an American Heart Association postdoctoral fellowship to lead the development of intravital multiphoton microscopy of the beating mouse heart and has used this to discover essential insight into how the heart functions in health and disease.

In his spare time, David is continually looking for dingos and kangaroos, trying to keep warm in the snow, and one day hopes people can understand his accent.

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