The use of large animals as intermediate models in immunological research has been hampered by the availability of immune reagents for many years. The U.S. Veterinary Immune Reagent Network is collaborative project funded by the USDA to develop key reagents for immunological research in domestic animals. Reagents for five species (cattle, pig, horse, poultry, and fish) are developed by three core facilities. Then, the new reagents will be distributed to the species communities for further characterization and testing.
More than 50 laboratories within the United States participate in this network. Our group at Cornell is one of the three core facilities producing recombinant proteins (immunoglobulins, TCRs, cytokine and chemokine receptors, and various CD molecules) for all species. We use a novel equine IgG fusion protein expression system that our laboratory has developed previously and that has already been used successfully to develop various recombinant proteins and monoclonal antibodies for immunological research in large animals.
Please also see our list of monoclonal specific equine cytokines, chemokines, immunoglobulins, and CD markers developed by the Wagner lab. If you are interested in learning more or obtaining monoclonal antibodies, please contact Dr. Bettina Wagner.
References
Larson EM, Babasyan S, Wagner B
J Immunol. 2021 May 15;206(10):2312-2321. doi: 10.4049/jimmunol.2001354. Epub 2021 May 5.
Schnabel CL, Babasyan S, Freer H, Larson EM, Wagner B
Vet Immunol Immunopathol. 2021 Aug;238:110284. doi: 10.1016/j.vetimm.2021.110284. Epub 2021 Jun 10.
Schnabel CL, Wemette M, Babasyan S, Freer H, Baldwin C, Wagner B
Vet Immunol Immunopathol. 2018 Oct;204:28-39. doi: 10.1016/j.vetimm.2018.09.003. Epub 2018 Sep 11.
CXCL10 production in equine monocytes is stimulated by interferon-gamma
Schnabel CL, Babasyan S, Freer H, Wagner B
Vet Immunol Immunopathol. 2019 Jan;207:25-30. doi: 10.1016/j.vetimm.2018.11.016. Epub 2018 Nov 24.
A monoclonal antibody for detection of intracellular and secreted interleukin-2 in horses
Freer H, Hillegas JM, Wimer C, Baldwin C, LaBresh J, Wagner B
Vet Immunol Immunopathol. 2017 Sep;191:30-35. doi: 10.1016/j.vetimm.2017.07.011. Epub 2017 Jul 31.
Quantification of equine immunoglobulin A in serum and secretions by a fluorescent bead-based assay
Schnabel CL, Babasyan S, Freer H, Wagner B
Vet Immunol Immunopathol. 2017 Jun;188:12-20. doi: 10.1016/j.vetimm.2017.04.001. Epub 2017 Apr 10.
Generation and characterization of a monoclonal antibody against canine tissue factor
Stokol T, Daddona J, DeLeonardis C, Dong L, Wagner B
Vet Immunol Immunopathol. 2015 Oct 15;167(3-4):178-84. doi: 10.1016/j.vetimm.2015.07.001. Epub 2015 Jul 3.
Production of seven monoclonal equine immunoglobulins isotyped by multiplex analysis
Keggan A, Freer H, Rollins A, Wagner B
Vet Immunol Immunopathol. 2013 Jun 15;153(3-4):187-93. doi: 10.1016/j.vetimm.2013.02.010. Epub 2013 Feb 19.
Wattrang E, Palm AK, Wagner B
Vet Immunol Immunopathol. 2012 Apr 15;146(2):113-24. doi: 10.1016/j.vetimm.2012.02.004. Epub 2012 Feb 16.
Wagner B, Burton A, Ainsworth D
Vet Res. 2010 Jul-Aug;41(4):47. doi: 10.1051/vetres/2010019. Epub 2010 Apr 9.
Monoclonal antibodies to equine CD14
Kabithe E, Hillegas J, Stokol T, Moore J, Wagner B
Vet Immunol Immunopathol. 2010 Nov 15;138(1-2):149-53. doi: 10.1016/j.vetimm.2010.07.003. Epub 2010 Jul 31.
Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses
Wagner B, Freer H
Vet Immunol Immunopathol. 2009 Feb 15;127(3-4):242-8. doi: 10.1016/j.vetimm.2008.10.313. Epub 2008 Oct 18.
Wagner B, Hillegas JM, Flaminio MJ, Wattrang E
Vet Immunol Immunopathol. 2008 Oct 15;125(3-4):315-25. doi: 10.1016/j.vetimm.2008.05.016. Epub 2008 May 24.
Wagner B, Hillegas JM, Brinker DR, Horohov DW, Antczak DF
Vet Immunol Immunopathol. 2008 Mar 15;122(1-2):57-64. Epub 2007 Oct 24.
Wagner B, Glaser A, Hillegas JM, Erb H, Gold C, Freer H
Vet Immunol Immunopathol. 2008 Mar 15;122(1-2):46-56. Epub 2007 Dec 3.
A monoclonal antibody to equine interleukin-4
Wagner B, Hillegas JM, Antczak DF
Vet Immunol Immunopathol. 2006 Apr 15;110(3-4):363-7. Epub 2006 Feb 9.
Wagner B, Robeson J, McCracken M, Wattrang E, Antczak DF
Vet Immunol Immunopathol. 2005 May 1;105(1-2):1-14.
Wagner B, Miller DC, Lear TL, Antczak DF
J Immunol. 2004 Sep 1;173(5):3230-42.