Neonatal Mechanisms of Tolerance Induction

Our previous findings showed that foals do not produce IgE antibodies for almost the first year of life. However, clearly detectable amounts of IgE are transferred from mares to offspring with the colostrum after birth. In this project, we test how maternal IgE influences the susceptibility to allergy in neonates.

 

References

  1. Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals

    Wagner B, Burton A, Ainsworth D

    Vet Res. 2010 Jul-Aug;41(4):47. doi: 10.1051/vetres/2010019. Epub 2010 Apr 9.

  2. Induction of interleukin-4 production in neonatal IgE+ cells after crosslinking of maternal IgE

    Wagner B, Stokol T, Ainsworth DM

    Dev Comp Immunol. 2010 Apr;34(4):436-44. doi: 10.1016/j.dci.2009.12.002. Epub 2009 Dec 16.

  3. Serum interleukin-6 (IL-6) and IL-10 concentrations in normal and septic neonatal foals

    Burton AB, Wagner B, Erb HN, Ainsworth DM

    Vet Immunol Immunopathol. 2009 Dec 15;132(2-4):122-8. doi: 10.1016/j.vetimm.2009.05.006. Epub 2009 May 18.

  4. Occurrence of IgE in foals: evidence for transfer of maternal IgE by the colostrum and late onset of endogenous IgE production in the horse

    Wagner B, Flaminio JB, Hillegas J, Leibold W, Erb HN, Antczak DF

    Vet Immunol Immunopathol. 2006 Apr 15;110(3-4):269-78. doi: 10.1016/j.vetimm.2005.10.007. Epub 2005 Dec 15.