Neonatal Mechanisms of Tolerance Induction

Our previous findings showed that foals do not produce IgE antibodies for almost the first year of life. However, clearly detectable amounts of IgE are transferred from mares to offspring with the colostrum after birth. In this project, we test how maternal IgE influences the susceptibility to allergy in neonates.

Related publications:

  1. Wagner B, Burton A, and Ainsworth DM. 2010. Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals. Vet. Res., 41: 47. VIEW ABSTRACT
  2. Wagner B, Stokol T and Ainsworth DM. 2010. Induction of interleukin-4 production in neonatal IgE+ cells after crosslinking of maternal IgE. Dev. Comp. Immunol., 34: 436-444. VIEW ABSTRACT
  3. Burton AB, Wagner B, Erb HN and Ainsworth DM. 2009. Serum interleukin-6 (IL-6) and IL-10 concentrations in normal and septic neonatal foals. Vet. Immunol. Immunopathol., 132: 122-128. VIEW ABSTRACT
  4. Wagner B, Flaminio JBF, Hillegas J, Leibold W, Erb HN, and Antczak DF. 2006. Occurrence of IgE in foals: evidence for transfer of maternal IgE by the colostrum and late onset of endogenous IgE production in the horse. Vet. Immunol. Immunopathol., 110: 269-278. VIEW ABSTRACT