IgG Isotypes in Disease and Vaccination

The evolution of equine immunoglobulin genes and their corresponding antibodies has been one of our major projects in the past, resulting in the discovery of former unknown antibody isotypes of the horse. Our current studies of functional roles that the seven equine IgG antibodies play during immune responses of the horse focus on infectious diseases, such as West Nile virus and Equine Herpes virus type I infection. We have found that specific isotypes are indicative for protection to these viral diseases. Although the correlation between Ig isotypes and T-cell mediated immunity is known for a long time in mice, it has almost been ignored in other animals. The goal is to use IgG isotypes as easily accessible parameters for T-cell mediated immunity during vaccination and the development of new vaccines in horses.

Related publications:

  1. Wagner B. 2006. Immunoglobulins and immunoglobulin genes of the horse. Dev. Comp. Immunol. 30: 155-164. VIEW ABSTRACT
  2. Wagner B, Miller WH, Morgan EE, Hillegas JM, Erb HN, Leibold W, and Antczak DF. 2006. IgE and IgG antibodies in skin allergy of the horse. Vet. Res. 37: 813-825. VIEW ABSTRACT
  3. Goodman LB, Wagner B, Flaminio MJ, Sussman KH, Metzger SM, Holland R, and Osterrieder N. 2006. Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1). Vaccine. 24: 3636-3645. VIEW ABSTRACT
  4. Wagner B, Miller DC, Lear TL, and Antczak DF. 2004. The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse. J. Immunol. 173: 3230-3242. VIEW ABSTRACT