Cytokines as Indicators of Cellular Immunity

The host immune system uses cellular and antibody mediated mechanisms that synergistically work together to attack pathogens, cure infection and provide protective long-term immunity after exposure. West Nile virus (WNV) and Equine Herpes virus type 1 (EHV-1) are used to investigate immune responses to intracellular pathogens after vaccination and natural infection in horses. Our objective is to provide a rapid, reliable and cost effective system to measure the ability of new vaccines to stimulate the host's cellular immunity.

Related publications:

  1. Wagner B and Freer H. 2009. Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses. Vet Immunol Immunopathol. 127: 242-348. VIEW ABSTRACT
  2. Wagner B, Glaser A, Hillegas JM, Erb H, Gold C, and Freer H. 2008. Monoclonal antibodies to equine IgM improve the sensitivity of West Nile virus-specific IgM detection in horses. Vet Immunol Immunopathol. 122: 46-56. VIEW ABSTRACT