Back Row (l-r): Hans Winkler, Shelagh Johnston, Colin Parrish, Matt Hints, Jessica Hayward, Laura Goodman, Leigh MacAyeal,
Front Row (l-r): Wendy Weichert, S. Michael Lyi, Carole Harbison, Karla Stucker
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Principal Investigator |  |
Colin Parrish
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Lab Members |  |
S. Michael Lyi
Michael is working on the processes of cytoplasmic and nuclear transport of the CPV capsids, and the role of the transferrin receptor in the endocytosis and infection of the CPV and FPV viruses. He is an expert in microinjection and live cell microscopy. |
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Jessica Hayward
Jess is from New Zealand, and is looking at the molecular evolution of Canine Influenza Virus (CIV), the result of a recent host species jump of Equine Influenza Virus H3N8. In particular, she is interested in the viral diversity and transmission dynamics of CIV in dog populations to better understand how this virus has adapted to, and persists in, its new host. |
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Laura Goodman
Laura works on CPV-TfR binding, antibody neutralization, and host range. She is using directed evolution to engineer affinity variants of the TfR and viral binding antibodies to understand the structural interactions between those ligands and viruses. Laura has an interdisciplinary background, with experience in molecular epidemiology and pathogenesis and global environmental change.
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Carole Harbison
Carole is examining the processes of cell infection controlled by the transferrin receptor, in particular the endosomal trafficking and the processes of binding to the cell surface. She is examining receptors with alterations that change the affinity of attachment and engagement with the endosomal trafficking processes, particularly the clathrin-medited uptake. |
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Karla Stucker
Karla is using CPV to study the molecular mechanisms
underlying viral emergence, with the ultimate objective being to identify
strategies for controlling and preventing emergence events. Specifically,
she isstudying how capsid changes acquired during CPV emergence and
adaptation have altered virus interactions with host cells, allowing for
more efficient infection. |
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Eric Strobel |
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Jason Kaelber |
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Natalie Johnson
Natalie is working on mapping the contacts between canine parvovirus and the
transferrin receptor, using site-directed mutagenesis and expression of the
feline and canine receptors in CHO cells. These constructs are
characterized for their ability to allow virus binding and infectivity using
fluorescence microscopy. Natalie is active in a number of campus volunteer
organizations including Cornell Elderly Partnership, and plans to attend
medical school after graduation. |
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Bobby Yu |
cy75@cornell.edu |
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Wendy Weichert
Wendy began working in the Parrish Lab in June 1993. She has a BS in Animal Science from Cornell University. Her role as lab manager evolves with our projects and often includes support of and/or involvement with several projects simultaneously. |
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Virginia Scarpino |
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Shelagh Johnston |
